I'm playing on widescreen, so can't really afford for my UI to take whole bottom part (that's why I had to drop eePanels, although it looked cool, I had only half of my screen visible :/), that's why it's scattered all aroud.
Target and focus buffs show also debuffs, obviously, so I can see when my ignite's going to end on target and when the sheep is gonna break on focus. Quartz also gives me a great cast bar (under Cryolysis), with latency embeded, so I can see when is the actual time my spells stop casting.
Cryolysis is a blessing <3 Buttons, from the top, clockwise: evocation (shows cooldown), free button 1 (fire/frost ward for me), buffs menu (opens on r-click), mount/hs, teleport/portal menu, free button 2 (trinkets for me), conjure/eat/trade food, conjure/drink/trade water, conjure/use mana gems, free button 3 (invisibility/spellsteal for me). Also gives a sound warning on sheep break and has some hilarious random speach for sheeping/portaling. Ah, and it restocks your mage's reagent, too.
When I'm in group, decursive boxes appear in the empty place under the target of target frames. i think I'll have to move them for raiding, there'll be too many boxes to fit there...
Enhanced chat box thanks to the Minimalist addon.
For my shammy it's basically the same, only more cluttered, as there's the BIG Healbot window over the focus frame. I also use Recount damage meter for showing off my uber healing
I should probably ditch the CTRaid frames, as it's redundant with my Healbot, but I can't for some reason. Doh. And yes, I have too little HP. Should do some BGs for PVP gear, but I hate it. :/
Also, using BigWigs for boss encounters, mostly because of the cool Final Fantasy winning music after we kill a boss.

Also, it's more accurate and it has a LittleWigs mod for 5men bosses, too.